How much should I expect to pay for Humalog U-100?

Prescription drug prices can be confusing. Two people may pay different prices for the same drug, depending on their insurance situation.

The list price1 of a 5-pack of 3 mL Humalog U-100 KwikPens (15 mL or 15,000 units) is $530.40 and the list price of a Humalog U-100 10 mL (10,000 units) vial is $274.70, but the amount you pay will largely depend on your prescription drug insurance plan. Insulin needs vary significantly from person to person, some take only 5 units per meal while others take over 100 units per meal. Given this variability, providing a relevant average cost for a month’s supply of Humalog U-100 is difficult. The information below will give you a good idea of what to expect based on your insurance and support that may be available to you.

For the most accurate information, talk to your insurance provider who knows the details of your plan.

Which Option Below Best Describes Your Insurance Situation?

About 80% of Humalog U-100 prescriptions cost between $0 and $30 per month, and the remaining cost an average of $135 (vial) or $130 (5-pack KwikPens) per month.2

What you pay for Humalog U-100 will depend on your insurance plan. Each plan has different preferred drug lists and out-of-pocket amounts, and most include an annual deductible. If you haven't met your deductible, you'll see higher prices and could pay full retail price until you meet your deductible.

For personalized assistance on the most affordable options for you, please call the Lilly Diabetes Solution Center at 1-833-808-1234, Monday-Friday, 9 a.m. to 8 p.m. Eastern Time.

For most patients with Medicare Part D coverage, out-of-pocket costs can vary throughout the year depending on which phase of the Part D benefit you are currently in. About 75% (vial) or 78% (5-pack KwikPens) of Humalog U-100 prescriptions cost between $0 and $100 a month, and the remaining cost an average of $178 (vial) or $187 (5-pack KwikPens) per month.2

Some Medicare patients qualify for extra financial support through the Extra Help3 program. If you are eligible for Extra Help, you can expect to pay $3 to $9 for each prescription.4

If you are unsure whether you qualify for Extra Help and would like more information, please visit: https://www.ssa.gov/benefits/medicare/prescriptionhelp/.

For personalized assistance on the most affordable options for you, please call the Lilly Diabetes Solution Center at 1-833-808-1234, Monday-Friday, 9 a.m. to 8 p.m. Eastern Time.

For most people on Medicaid, out-of-pocket costs for prescription drugs like Humalog U-100 range from $4 to $9 per month.5 Some states allow even lower copays or eliminate the copay requirement altogether.

To find out if you qualify for Medicaid, or for more information about copayments in your state, please visit: https://www.medicaid.gov/state-overviews/index.html.

For personalized assistance on the most affordable options for you, please call the Lilly Diabetes Solution Center at 1-833-808-1234, Monday-Friday, 9 a.m. to 8 p.m. Eastern Time.

If you do not have prescription drug coverage6 or if your insurance does not cover Humalog, you can expect to pay close to the list price shown above, plus any additional pharmacy charges depending on where you purchase your medicine.

For personalized assistance on the most affordable options for you, please call the Lilly Diabetes Solution Center at 1-833-808-1234, Monday-Friday, 9 a.m. to 8 p.m. Eastern Time.

Want More Information?

For personalized assistance on the most affordable options for you, please call the Lilly Diabetes Solution Center at 1-833-808-1234, Monday-Friday, 9 a.m. to 8 p.m. Eastern Time. Although we won't replace the advice of your healthcare provider, we'll do our best to help find affordable options for you.

Need Another Option?

Lilly donates medicines to the Lilly Cares Foundation, a separate nonprofit organization that helps qualified people in need receive Lilly medicines at no cost. Learn more at www.lillycares.com or by calling Lilly Cares at 1-800-545-6962.

1 List price, also referred to as wholesale acquisition cost or WAC, is the price at which Lilly sells its products to wholesalers and may not represent actual transactional prices patients pay at the pharmacy. 2019. AnalySource accessed on July 3, 2019. Reprinted with permission by First Databank, Inc. All rights reserved. ©2019. https://www.fdbhealth.com/policies/drug-pricing-policy/

2 Source: Based on internal analysis of IQVIA Longitudinal Access and Adjudication Data (LAAD) – Humalog U-100 Patient OOP Cost per Script by Channel (April 2018 – March 2019). Accessed on July 26, 2019. Employer or Private Individual Policy Insurance reflects commercial savings card and other support. Medicare Part D Coverage reflects supplemental support.

3 Social Security Administration (SSA). Extra Help with Medicare Prescription Drug Plan Costs. https://www.ssa.gov/benefits/medicare/prescriptionhelp/. Accessed on July 24, 2019.

4 Centers for Medicare & Medicaid Services (CMS). Announcement of Calendar Year (CY) 2019 Medicare Advantage Capitation Rates and Medicare Advantage and Part D Payment Policies and Final Call Letter. Attachment V Final 2019 Benefit Design Parameters. https://www.cms.gov/Medicare/Health-Plans/MedicareAdvtgSpecRateStats/Downloads/Announcement2019.pdf. Accessed on July 24, 2019.

5 Centers for Medicare & Medicaid Services (CMS). Medicaid and CHIP Overview for Assisters. Maximum Allowable Copayments Determined by Eligible Population's Household Income. Updated August 2018. **All out-of-pocket charges are based on the specific state's defined payment amount for that service. Certain groups, including children, terminally ill individuals, and individuals residing in an institution are exempt from cost sharing. Refer to yourstate agency for details about Medicaid out-of-pocket costs. https://marketplace.cms.gov/technical-assistance-resources/fast-facts-medicaid-chip.pdf. Accessed on July 24, 2019.

6 Most people have some type of health insurance coverage that includes a prescription drug benefit. According to recent data, just under 9% of the total U.S. population is uninsured. https://www.kff.org/state-category/health-coverage-uninsured/health-insurance-status/.

INDICATION AND IMPORTANT SAFETY INFORMATION
INDICATION

Humalog and Insulin Lispro Injection are used to treat people with diabetes for the control of high blood sugar.

Important Safety Information
What is the most important information I should know about Humalog U-100, Humalog U-200, Humalog Mix75/25, Humalog Mix50/50, and Insulin Lispro Injection?
  • Do not share your Humalog U-100, Humalog U-200, Humalog Mix75/25, Humalog Mix50/50, or Insulin Lispro Injection prefilled pen, cartridges, reusable pen compatible with Lilly 3 mL cartridges, needles, or syringes with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.
  • Do not change the type or amount of insulin you use without talking to your healthcare provider. Changes may make you more likely to experience low or high blood sugar. Changes should be made cautiously under the supervision of your healthcare provider.
  • Check your blood sugar levels as your healthcare provider instructs.
  • The amount of insulin and the best time for you to take your dose may need to change if you take different types of insulin or because of illness, increased stress, other medicines you take, change in diet, weight gain or loss, or change in physical activity or exercise.
  • Humalog U-200 must ONLY be injected with the Humalog U-200 KwikPen. The Humalog U-200 KwikPen contains 2 times as much insulin (200 units/mL) in 1 mL as standard insulin (100 units/mL). Do not withdraw Humalog U-200 from your KwikPen using a syringe. It could result in an overdose causing severe low blood sugar which may put your life in danger.
Who should not take Humalog U-100, Humalog U-200, Humalog Mix75/25, Humalog Mix50/50, or Insulin Lispro Injection?
  • Do not take these insulins if your blood sugar is too low (hypoglycemia) or if you are allergic to insulin lispro or any of the ingredients in these insulins.
What should I tell my healthcare provider before taking Humalog U-100, Humalog U-200, Humalog Mix75/25, Humalog Mix50/50 or Insulin Lispro Injection?
Tell your healthcare provider about all of your medical conditions and all of the medicines you take, including if you:
  • have heart failure or other heart, liver, or kidney problems
  • are pregnant, breastfeeding, or plan to become pregnant or breastfeed.
  • take medicines commonly called TZDs (thiazolidinediones) or any other prescription or over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of Humalog U-100, Humalog U-200, Humalog Mix75/25, Humalog Mix50/50 and Insulin Lispro Injection?
  • Low blood sugar is the most common side effect. Severe low blood sugar may put your life in danger and can cause seizures or death. Signs and symptoms of low blood sugar may be different for each person and may include dizziness or light-headedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability or mood changes, and hunger. Your healthcare provider may prescribe a glucagon emergency kit if your blood sugar becomes too low and you are unable take sugar by mouth. Be sure to talk to your healthcare provider about low blood sugar and how to manage it.
  • Severe life-threatening allergic reactions (whole-body reactions) can happen. Get medical help right away if you have: a rash over your whole body, trouble breathing, shortness of breath, a fast heartbeat, swelling of your face, tongue or throat, sweating, extreme drowsiness, dizziness, or confusion.
  • Humalog U-100, Humalog U-200, Humalog Mix75/25, Humalog Mix50/50, and Insulin Lispro Injection can cause life-threatening low potassium in your blood (hypokalemia). This can cause severe breathing problems, irregular heartbeat, and death.
  • Swelling of your hands and feet and heart failure may occur when taking certain pills called thiazolidinediones or “TZDs” with Humalog U-100, Humalog U-200, Humalog Mix75/25, Humalog Mix50/50, or Insulin Lispro Injection. This can happen in some people even if they have not had heart problems before. Tell your healthcare provider if you have shortness of breath, swelling of your ankles or feet, or sudden weight gain, which may be symptoms of heart failure. Your healthcare provider may need to adjust or stop your treatment with TZDs and Humalog U-100, Humalog U-200, Humalog Mix75/25, Humalog Mix50/50, or Insulin Lispro Injection.
  • Failure of your insulin pump or infusion set or degradation of the insulin in the pump can cause hyperglycemia and ketoacidosis. Always carry an alternate form of insulin administration in case of pump failure.
  • The most common side effects of Humalog U-100, Humalog U-200, Humalog Mix75/25, Humalog Mix50/50, and Insulin Lispro Injection include: low blood sugar, allergic reactions, including reactions at your injection site, skin thickening or pits at the injection site (lipodystrophy), weight gain, swelling in your hands or feet, itching, and rash.

These are not all of the possible side effects. Ask your healthcare provider for more information or for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
How should I take Humalog U-100, Humalog U-200, Humalog Mix75/25, Humalog Mix50/50, or Insulin Lispro Injection?
  • Check your insulin label before each injection to make sure you are taking the correct type of insulin.
  • Do not re-use needles. Always use a new needle for each injection. Re-use of needles can cause you to get the wrong dose of insulin or result in a serious infection.
  • These insulins start acting fast. Inject Humalog U-100, Humalog U-200, or Insulin Lispro Injection within fifteen minutes before or right after eating a meal. Inject Humalog Mix75/25 or Humalog Mix50/50 within fifteen minutes before you eat a meal.
  • Inject your insulin under your skin (subcutaneously). Never inject into a vein or muscle. Change (rotate) your injection site with each dose.
  • Never mix Humalog U-200, Humalog Mix75/25, or Humalog Mix50/50 with other insulins or liquids. Never use Humalog U-200, Humalog Mix75/25, or Humalog Mix50/50 in a pump.
  • Do not drive or operate heavy machinery until you know how Humalog U-100, Humalog U-200, Humalog Mix75/25, Humalog Mix50/50, or Insulin Lispro Injection affects you.
  • Do not drink alcohol or take medicines that contain alcohol while taking Humalog U-100, Humalog U-200, Humalog Mix75/25, Humalog Mix50/50, or Insulin Lispro Injection.

Humalog U-100, Humalog U-200, Humalog Mix75/25, Humalog Mix50/50, and Insulin Lispro Injection are available by prescription only.

For additional information talk to your healthcare providers and please click to access Humalog Full Prescribing Information, Humalog U-100 Patient Prescribing Information, Humalog U-200 Patient Prescribing Information, Humalog Mix75/25 Full Prescribing Information and Patient Prescribing Information, Humalog Mix50/50 Full Prescribing Information and Patient Prescribing Information, Insulin Lispro Injection Full Prescribing Information and Patient Prescribing Information.

Please click to access Humalog U-100 KwikPen Instructions for Use, Humalog Junior KwikPen Instructions for Use, Humalog U-100 Vial Instructions for Use, Humalog U-200 KwikPen Instructions for Use, Humalog Mix75/25 KwikPen Instructions for Use, Humalog Mix75/25 Vial Instructions for Use, Humalog Mix50/50 KwikPen Instructions for Use, Humalog Mix50/50 Vial Instructions for Use, Insulin Lispro Injection KwikPen Instructions for Use and Insulin Lispro Injection Vial Instructions for Use

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